- Prazosin is a medication that belongs to a class of drugs known as alpha-1 adrenergic blockers.
- It works by relaxing and widening blood vessels, which helps to lower blood pressure.
- It is primarily used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (BPH).
Chemical Structure & Formula:
- A quinazoline derivative with a piperazine ring attached to the quinazoline nucleus.
- Approximate Formula: C₂₁H₂₅N₅O₄
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Mechanism of Action:
- Selectively antagonizes postsynaptic α₁ receptors.
- Inhibits norepinephrine-mediated vasoconstriction, thereby inducing vasodilation with minimal impact on presynaptic α₂ receptors.
Side Effects of Prazosin:
- Dizziness and lightheadedness (especially on standing)
- Headache
- Fatigue
- Orthostatic hypotension
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Clinical Uses of Prazosin:
- Used in the treatment of hypertension and off-label for urinary symptoms in benign prostatic hyperplasia (BPH).
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