Prednisolone is a corticosteroid used to treat inflammation, allergies, and autoimmune disorders by suppressing immune response.
Structure of Prednisolone
- Prednisolone is a synthetic glucocorticoid with a modified steroid structure, enhancing its anti-inflammatory potency.
- Chemical Formula: C₂₀H₂₈O₅
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Mode of Action
- Glucocorticoid Activity: Binds to glucocorticoid receptors, regulating gene transcription involved in inflammatory and immune responses.
- Anti-Inflammatory Effects: Suppresses the production of pro-inflammatory cytokines and mediators.
- Immunosuppression: Inhibits immune cell proliferation and function, reducing autoimmune and hypersensitivity reactions.
- Metabolic Effects: Alters carbohydrate, protein, and lipid metabolism, influencing glucose levels and fat distribution.
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Uses
- Inflammatory Conditions: Treats arthritis, asthma, and allergic reactions by mitigating inflammation.
- Autoimmune Diseases: Manages lupus, multiple sclerosis, and inflammatory bowel disease through immunosuppression.
- Endocrine Disorders: Used in adrenal insufficiency to replace deficient cortisol.
- Skin Disorders: Applied topically to reduce inflammation and treat dermatitis, eczema, and psoriasis.
- Cancer Therapy: Adjunct in chemotherapy regimens to reduce inflammation and manage side effects.
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