- Primidone metabolizes to phenobarbital and PEMA, enhancing GABA to reduce neuronal excitability.
- It is prescribed for epilepsy, controlling partial and generalized tonic-clonic seizures.
Formula:
- C₁₂H₁₄N₂O₂
Mechanism of Primidone:
- GABA-A enhancement via phenobarbital metabolite
- Direct Na⁺ channel effects
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Uses of Primidone:
- Generalized tonic-clonic seizures
- Essential tremor
Side Effects:
- Sedation
- Nausea
- Ataxia
Notes:
Used in patients who respond poorly to phenytoin
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