Quinapril Hydrochloride is an ACE inhibitor used to manage hypertension and heart failure by lowering blood pressure through vasodilation.
Structure of Quinapril Hydrochloride
- It is a prodrug ACE inhibitor with a quinoline ring fused to a pyrrolidine moiety.
- Chemical Formula: C₂₈H₃₈N₃O₆S·HCl
Mode of Action
- Prodrug Activation: Converted to quinaprilat, the active metabolite.
- ACE Inhibition: Blocks the formation of angiotensin II, promoting vasodilation.
- Vasodilation: Reduces systemic vascular resistance and arterial pressure.
- Renal Effects: Decreases glomerular pressure, offering renal protection.
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Uses
- Hypertension: Lowers blood pressure by inhibiting ACE activity.
- Heart Failure: Enhances cardiac performance by reducing afterload and preload.
- Post-Myocardial Infarction: Prevents adverse cardiac remodeling and improves survival.
- Diabetic Nephropathy: Slows the progression of kidney damage in diabetic patients.
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