Rabeprazole, a potent gastric proton pump inhibitor, reduces stomach acid to treat GERD, peptic ulcers, and acid-related disorders.
Structure of Rabeprazole
- It is a benzimidazole derivative with a pyridine ring fused to a benzimidazole core, containing a sulfone group and an ethoxy methyl group.
- Chemical Formula: C₁₈H₂₀N₄O₅S
Mode of Action
- Rabeprazole functions as a proton pump inhibitor by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme in gastric parietal cells.
- It blocks the final step of acid production, resulting in prolonged acid suppression.
Uses
- Peptic Ulcers: Aids in ulcer healing by reducing gastric acid.
- GERD: Alleviates acid reflux symptoms.
- Zollinger-Ellison Syndrome: Manages excessive gastric acid secretion.
- Erosive Esophagitis: Heals damage and inflammation in the esophagus.
- Helicobacter pylori Eradication: Part of combination therapy to eliminate H. pylori infection.
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