Risperidone

  • Risperidone blocks dopamine D2 and serotonin 5-HT2 receptors, stabilizing mood and behavior.
  • It treats schizophrenia, bipolar disorder, and irritability in autism spectrum disorder.

Chemical Formula:

  • C₂₃H₂₇FN₄O₂

 Chemical Structure of Risperidone

Mechanism of Risperidone:

  • Antagonist at D2 and 5-HT2A
  • Also affects α1, H1 receptors

Uses of Risperidone:

  • Schizophrenia
  • Bipolar disorder
  • Irritability in autism
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Side Effects:

  • Moderate EPS (esp. at high doses)
  • Weight gain
  • Hyperprolactinemia
  • Orthostatic hypotension

Notes:

  • First-line atypical antipsychotic
  • Available in long-acting injectable (Risperdal Consta)

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