Rosiglitazone is a thiazolidinedione antidiabetic drug that enhances insulin sensitivity to help manage blood sugar in type 2 diabetes.
Structure of Rosiglitazone
- It is a TZD with a similar core structure to pioglitazone but contains a different aromatic substituent, enhancing its potency.
- Chemical Formula: C₁₉H₂₅N₃O₃S
Mode of Action
- PPAR-γ Agonism: Increases insulin sensitivity in peripheral tissues.
- Anti-Inflammatory Effects: Reduces inflammatory markers associated with insulin resistance.
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Uses of Rosiglitazone
- Type 2 Diabetes Mellitus: Enhances insulin sensitivity to improve glycemic control.
- Metabolic Syndrome: Assists in managing insulin resistance and dyslipidemia.
Note
- Cardiovascular Risks: Associated with increased risk of myocardial infarction; usage restricted or monitored closely in many regions.
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