Senna (Anthraquinone Glycosides)

General Introduction to Senna (Anthraquinone Glycosides):

• Senna contains anthraquinone glycosides, which are widely used as stimulant laxatives.
• The plant is recognized for its purgative effect on the gastrointestinal system.

Synonyms of Senna (Anthraquinone Glycoside):

• Common name: Senna
• Scientific name: Cassia angustifolia, Cassia acutifolia
• Synonyms: Indian Senna, Tinnevelly Senna, Alexandrian Senna

Biological Source:

• Derived from the dried leaflets and pods of Cassia angustifolia and Cassia acutifolia.

Family:

• Fabaceae

Composition:

• Major glycosides:
  • Sennosides A and B: Main active anthraquinone glycosides.
  • Other anthraquinones: Rhein, Aloe-emodin, Chrysophanol.

Chemistry & Chemical Classes:

• Chemical Class: Anthraquinone glycosides.
• Structure:
  • Sennosides are dimeric glycosides formed from two anthraquinone units.
  • They are hydrolyzed in the colon to release active anthraquinones.

Therapeutic Uses:

• Laxative: Used to treat constipation by stimulating peristalsis in the colon.
• Purgative: At higher doses, it induces bowel evacuation.

Commercial Applications of Senna (Anthraquinone Glycoside):

• Used in over-the-counter laxative preparations such as syrups, tablets, and granules.

Click Here to Watch the Best Pharma Videos