Size of Capsules

• Size of capsules refers to the standardized dimensions of empty capsules, indicating their volume capacity. They range from 000 (largest) to 5 (smallest), used to encapsulate varying drug doses.
• Size of capsules determines the fill weight and patient compliance. Proper size selection ensures accurate dosing, ease of swallowing, and suitability for the intended formulation.
• Soft gels capsules come in various sizes and shapes (oval, round, oblong, tube-shaped).
• The specific size is selected based on:
  1. Volume of Fill: The intended dose of the active ingredient and the required excipients.
  2. Manufacturing Constraints: Larger capsules can be more challenging to seal and handle.
  3. Patient Compliance: Overly large capsules can be difficult to swallow.
• Soft gelatin capsules come in various sizes and shapes, such as oblong, oval, round, or tube-like forms. The choice of size depends on:
• Volume of the liquid or semi-solid content to be encapsulated.
• Patient acceptability and ease of swallowing.

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