- Soft gelatin capsules (soft gels) are a specialized form of capsules made from a single, pliable shell that encapsulates liquid or semi-solid formulations.
- Soft gelatin capsules are widely used in the pharmaceutical, nutraceutical, and cosmetic industries for delivering active pharmaceutical ingredients (APIs), oils, or other bioactive compounds.
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Key Features of Soft Gelatin Capsule:
- Composed of a gelatin-based shell that is soft, elastic, and easily dissolves in the gastrointestinal tract.
- Typically used for liquid or semi-solid drug formulations.
- Provide protection for drugs sensitive to light, moisture, and oxidation.
Advantages:
- Mask unpleasant taste or odor of the drug.
- Enhance bioavailability, especially for poorly water-soluble drugs.
- Provide precise dosing with minimal variability.
- Allow customized release profiles (e.g., immediate, sustained, or enteric release).
- Enable rapid onset of action for certain drugs.
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Disadvantages:
- Not suitable for aqueous formulations (water can soften or dissolve the shell prematurely).
- Relatively higher production cost compared to other dosage forms.
- Requires specialized manufacturing equipment.
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