Effect of Solvent:
- Solvents can change the reaction medium, affecting:
- Solubility of the drug
- Polarity of the medium
- Hydrolysis or oxidation rate
- Some solvents may stabilize or destabilize the drug.
Co-solvent Systems:
- Adding solvents like ethanol can:
- Change solvation
- Affect reaction kinetics
- Modify degradation pathways
Examples:
- Hydrolysis is faster in aqueous solutions.
- Adding organic solvents like alcohol can slow hydrolysis by reducing water availability.
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