Sulindac

• Sulindac inhibits COX enzymes, lowering prostaglandin synthesis to reduce pain and swelling.
• It is an NSAID effective in treating arthritis, pain, and inflammation.

Chemical Formula:

• C₂₀H₁₇FO₃S

Mechanism of Action:

• Prodrug → converted to active sulfide metabolite
• Inhibits COX-1 and COX-2

Uses of Sulindac:

• RA, OA, gout
• Familial adenomatous polyposis (FAP) (off-label)

Side Effects of Sulindac:

• GI irritation (less than indomethacin)
• CNS disturbances
• Rare cholestatic hepatitis

SAR Notes:

• Sulfoxide group makes it a prodrug (less GI irritation)
• Fluoroaromatic ring enhances potency

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