Sulpiride

• Sulpiride is a selective dopamine D2 antagonist with antipsychotic and antidepressant effects.
•  It treats schizophrenia, depression, and anxiety by balancing dopamine activity.

Chemical Formula:

• C₁₅H₂₃N₃O₄S

Mechanism of Sulpiride:

• Selective D2 and D3 antagonist
• Low affinity for D1, 5-HT, or muscarinic receptors

Uses of Sulpiride:

• Schizophrenia (Europe, Asia)
• Dysthymia, depression (low doses)

Side Effects:

• Hyperprolactinemia
• Mild sedation
• Low EPS risk at low doses

Notes:

• Not FDA-approved in U.S.
• One of the cleanest dopaminergic antipsychotics

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