Tachyphylaxis is a rapid decrease in drug response after repeated doses in a short period, leading to reduced effectiveness.
Definition of Tachyphylaxis:
- Tachyphylaxis is a rapid decrease in drug response after repeated administration in a short time.
Key Features:
- Occurs quickly (within minutes to hours).
- Further dosing does not restore the effect.
Mechanism:
- Possible depletion of neurotransmitter stores.
- Desensitization or inactivation of receptors.
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Example of Tachyphylaxis:
- Ephedrine (indirect sympathomimetic): Causes tachyphylaxis due to depletion of norepinephrine.
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