Tacrine Hydrochloride

• Tacrine Hydrochloride is the hydrochloride salt form of Tacrine, a centrally acting cholinesterase inhibitor.
• It is primarily used in the management of mild to moderate Alzheimer’s disease to enhance cholinergic transmission in the brain by inhibiting the enzyme acetylcholinesterase.

Chemical Formula:

• C₁₃H₁₄ClN
• 

Mechanism of Action:

• Reversible AChE inhibitor; crosses BBB.
• Also has NMDA antagonist

Uses of Tacrine Hydrochloride:

• Alzheimer’s disease (no longer widely used due to hepatotoxicity)

Side Effects of Tacrine Hydrochloride:

• Hepatotoxicity
• Nausea, vomiting
• Dizziness
• GI upset

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!