Tadalafil is a PDE5 inhibitor used to treat erectile dysfunction and pulmonary hypertension by improving blood flow.
Structure of Tadalafil
- It is a PDE5 inhibitor with a similar core structure to sildenafil but with distinct substituents enhancing its pharmacokinetic profile.
- Chemical Formula: C₂₂H₂₉N₃O₄
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Mode of Action
- PDE5 Inhibition: Tadalafil selectively inhibits PDE5, preventing the breakdown of cGMP.
- cGMP Elevation: Leads to prolonged smooth muscle relaxation and vasodilation in the corpus cavernosum.
- Sustained Erection: Facilitates erection by enhancing blood flow in response to sexual stimulation, with a longer duration of action compared to sildenafil.
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Uses
- Erectile Dysfunction (ED): Treats erectile dysfunction by enhancing the natural erectile response.
- Benign Prostatic Hyperplasia (BPH): Alleviates symptoms of BPH, such as difficulty in urination.
- Pulmonary Arterial Hypertension (PAH): Used to lower pulmonary blood pressure, marketed as Adcirca®.
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