General Introduction to Taxus (Diterpenoids):
- Taxus (Yew tree) is a source of the diterpenoid paclitaxel, a potent anticancer agent.
Synonyms:
- Common name: Yew
- Scientific name: Taxus brevifolia, Taxus baccata
- Synonyms: Pacific Yew, European Yew
Biological Source:
- Derived from the bark of Taxus brevifolia and needles of Taxus baccata.
Family:
- Taxaceae
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Composition:
- Major diterpenoid:
- Paclitaxel (Taxol): The primary active compound.
Chemistry & Chemical Classes:
- Chemical Class: Diterpenoids.
- Structure:
- Paclitaxel is a complex diterpenoid with a taxane skeleton.
Therapeutic Uses of Taxus (Diterpenoids):
- Anticancer: Used in chemotherapy for breast, ovarian, and lung cancers.
Commercial Applications:
- Paclitaxel is marketed as Taxol in injectable formulations.
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