Thiotepa is an anti-neoplastic alkylating agent used to treat breast, ovarian, and bladder cancers by disrupting cancer cell DNA replication.
Structure of Thiotepa
- Thiotepa is a trivalent phosphoramide alkylating agent containing three chloroethyl groups attached to a nitrogen atom.
- Chemical Formula: C₆H₁₃Cl₃N₄O₂P
Mode of Action
- DNA Alkylation: Forms crosslinks within and between DNA strands, inhibiting DNA replication and transcription.
- Cell Cycle Arrest: Halts cancer cell division.
- Apoptosis Induction: Promotes programmed cell death in malignant cells.
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Uses
- Breast Cancer: Particularly in metastatic cases.
- Ovarian Cancer: As part of combination chemotherapy.
- Multiple Myeloma: Treatment in conjunction with other agents.
- Central Nervous System (CNS) Cancers: Such as primary brain tumors.
- Bone Marrow Transplantation: As part of conditioning regimens.
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