- Thiothixene blocks dopamine receptors, reducing psychotic symptoms with tranquilizing effect.
- It is an antipsychotic used to manage schizophrenia and related psychiatric disorders.
Chemical Formula:
- C₂₃H₂₉N₃OS₂
Mechanism of Thiothixene:
- Potent D2 antagonist
- Low activity at M1/H1 → less sedation, more EPS
Advertisements
Uses of Thiothixene:
- Schizophrenia
Side Effects:
- High EPS risk
- Akathisia
- Dystonia
- Less anticholinergic activity
SAR Note:
Piperazine ring = increased potency & EPS risk (similar to trifluoperazine)
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
