Tissue Protein Binding of Drugs

Tissue Protein Binding of Drugs influences drug storage, release, duration of action, and overall pharmacological effects.

Tissue Protein Binding of Drugs

• Tissue binding refers to the interaction between drugs and intracellular, extracellular, membrane, or receptor proteins in various organs, affecting drug distribution and elimination.

Mechanism of Tissue Protein Binding:

1. Intracellular Binding: Drugs bind to intracellular proteins (e.g., enzymes, nuclear proteins), influencing drug action within cells.
2. Extracellular Binding: Interaction with extracellular matrix proteins (e.g., collagen, fibronectin) affects drug retention in tissues.
3. Membrane Binding: Drugs bind to transporters and ion channels, affecting their cellular uptake and distribution.
4. Receptor Binding: Specific drugs bind to receptors to trigger a pharmacological response, which can be reversible or irreversible.

Clinical Significance of Drug Binding

• High plasma protein binding restricts drug distribution and slows elimination.
• Extensive tissue binding may prolong drug action or cause toxicity.
• Drug displacement from plasma proteins can increase free drug levels, affecting efficacy and safety.

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