- Tolmetin blocks COX enzymes, decreasing prostaglandins to relieve pain, fever, and inflammation.
- It is an NSAID used for osteoarthritis, rheumatoid arthritis, and juvenile arthritis.
Chemical Formula:
- C₁₅H₁₅NO₃
Mechanism of Action:
- Inhibits COX enzymes
- Also inhibits leukocyte migration (minor)
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Uses of Tolmetin:
- OA, RA, juvenile arthritis
Side Effects of Tolmetin:
- GI upset
- Headache
- Less frequent CNS effects than indomethacin
SAR Notes:
- Pyrrole ring contributes to COX affinity
- Acetic acid moiety critical for activity
