Transmembrane JAK-STAT Binding Receptors

  • Transmembrane JAK-STAT Binding Receptors are receptors that activate JAK kinases on ligand binding, triggering STAT pathways to regulate gene expression.
  • These receptors lack intrinsic kinase activity but associate with cytoplasmic enzymes, specifically Janus Kinases (JAKs).

Structure of Transmembrane JAK-STAT Binding Receptors:

  • Single transmembrane receptor
  • No intrinsic enzymatic domain

Transmembrane JAK-STAT Binding Receptors

Mechanism:

  1. Ligand (e.g., cytokine) binds to receptor
  2. Receptor dimerizes
  3. Associated JAKs become activated
  4. JAKs phosphorylate receptor tyrosines
  5. STAT proteins (Signal Transducers and Activators of Transcription) bind to phosphotyrosines
  6. STATs get phosphorylated, dimerize, and translocate to nucleus
  7. Bind DNA and regulate gene transcription
Advertisements

Response Time:

  • Hours

Examples:

  • Cytokine receptors (interleukins, interferons)
  • Growth hormone receptor
  • Prolactin receptor

Click Here to Watch the Best Pharma Videos!

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.

','

' ); } ?>