Transmembrane JAK-STAT Binding Receptors are receptors that activate JAK kinases on ligand binding, triggering STAT pathways to regulate gene expression.
- These receptors lack intrinsic kinase activity but associate with cytoplasmic enzymes, specifically Janus Kinases (JAKs).
Structure of Transmembrane JAK-STAT Binding Receptors:
- Single transmembrane receptor
- No intrinsic enzymatic domain
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Mechanism:
- Ligand (e.g., cytokine) binds to receptor
- Receptor dimerizes
- Associated JAKs become activated
- JAKs phosphorylate receptor tyrosines
- STAT proteins (Signal Transducers and Activators of Transcription) bind to phosphotyrosines
- STATs get phosphorylated, dimerize, and translocate to nucleus
- Bind DNA and regulate gene transcription
Response Time:
- Hours
Examples:
- Cytokine receptors (interleukins, interferons)
- Growth hormone receptor
- Prolactin receptor
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