Triamterene is a potassium-sparing diuretic used to treat edema and hypertension by reducing sodium reabsorption without potassium loss.
Structure of Triamterene
- Triamterene is a non-steroidal potassium-sparing diuretic with a triazine ring structure attached to an aromatic moiety and amine groups.
- Chemical Formula: C₁₆H₁₅N₃O₃
Mode of Action
- ENaC Inhibition: Blocks epithelial sodium channels (ENaC) in the collecting ducts, reducing sodium reabsorption.
- Potassium Retention: Promotes potassium retention by minimizing its excretion.
- Sodium Excretion: Enhances excretion of sodium and water without significant loss of potassium.
Advertisements
Uses
- Edema: Treats fluid retention in conditions like congestive heart failure and renal disease.
- Hypertension: Lowers blood pressure by promoting sodium excretion.
- Diuretic Combinations: Often combined with thiazides to enhance diuretic efficacy and prevent hypokalemia.
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
