- Triclofos Sodium is used as a sedative-hypnotic for treating childhood insomnia and sleep disorders.
- It is a chloral hydrate derivative, induces sleep by depressing the CNS safely in children.
Chemical Formula:
- C₈H₁₅Cl₃Na₂O₄P
Mechanism of Triclofos Sodium:
- Prodrug; hydrolyzed to trichloroethanol (active), similar to chloral hydrate.
- Acts on GABA-A receptor to enhance inhibitory neurotransmission.
Therapeutic Uses of Triclofos Sodium:
- Pediatric sedation
- Preoperative sedation
Advertisements
Side Effects:
- GI irritation
- CNS depression
- Hypotension
- Hepatotoxicity (rare)
Notes:
Used as an alternative to chloral hydrate in some pediatric settings.
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
