Trimethadione

• Trimethadione is prescribed for absence seizures when other treatments are ineffective
• It stabilizes neuronal activity by reducing T-type calcium currents in the thalamus..

Chemical Formula:

• C₆H₁₁NO₂

Mechanism of Action:

• Blocks T-type Ca²⁺ channels in thalamic neurons
• Reduces thalamocortical rhythmicity (key in absence seizures)

Therapeutic Uses of Trimethadione:

• Absence seizures (historical)
• Occasionally used in refractory cases

Side Effects of Trimethadione:

• Aplastic anemia
• Hepatotoxicity
• Trimethadione fetal syndrome (teratogenic)
• Sedation, vision disturbances

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