Two Compartment Open Model IV Bolus describes rapid drug distribution into central and peripheral compartments with elimination kinetics.
- Drug is administered rapidly into the central compartment.
- Distribution occurs between central and peripheral compartments.
- Elimination happens only from the central compartment.
- This model describes the pharmacokinetics of a drug administered intravenously in a single dose, where the drug distributes between a central and peripheral compartment.
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Phases:
- Alpha phase (distribution phase): Rapid decline in plasma concentration due to drug distribution into peripheral tissues.
- Beta phase (elimination phase): Slower decline due to metabolism and excretion.
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Equation:
$C(t) = A e^{-\alpha t} + B e^{-\beta t}$
- C(t) = drug concentration at time t
- A, B = intercepts
- $\alpha, \beta$ = rate constants for distribution and elimination
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Clinical Significance:
- Helps predict how quickly a drug distributes and how long it stays in the body.
- Important in drugs with significant tissue binding or large volumes of distribution.
