- Valproic Acid treats epilepsy, bipolar disorder, and prevents migraine attacks.
- It increases GABA levels, stabilizing neuronal firing and reducing seizures.
Formula:
- C₈H₁₆O₂
Mechanism of Action:
- Na⁺ channel blocker
- T-type Ca²⁺ channel inhibitor
- ↑ GABA levels by inhibiting GABA transaminase
Uses of Valproic Acid:
- Broad-spectrum AED (absence, myoclonic, tonic-clonic, partial)
- Bipolar disorder
- Migraine prophylaxis
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Side Effects of Valproic Acid:
- Hepatotoxicity (black box)
- Pancreatitis
- Tremor
- Teratogenicity (neural tube defects)
- Weight gain
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