Vinblastine Sulphate is an anti-neoplastic alkaloid used in cancers like Hodgkin’s lymphoma by inhibiting microtubule formation and cell division.
Structure of Vinblastine Sulphate
- Vinblastine is a vinca alkaloid comprising two monomers: catharanthine and vindoline, linked together.
- Chemical Formula: C₄₈H₅₈N₁₄O₁₂
Mode of Action
- Microtubule Inhibition: Binds to tubulin, preventing microtubule assembly and disassembly.
- Mitotic Arrest: Halts cell division at metaphase by disrupting spindle formation.
- Apoptosis Induction: Leads to programmed cell death in rapidly dividing cells.
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Uses
- Hodgkin’s Lymphoma: Often part of ABVD regimen.
- Non-Hodgkin’s Lymphoma: In various treatment protocols.
- Breast Cancer: Especially metastatic cases.
- Testicular Cancer: In combination with other chemotherapeutic agents.
- Bladder Cancer: As part of multi-agent chemotherapy regimens.
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