Vinblastine Sulphate

Vinblastine Sulphate is an anti-neoplastic alkaloid used in cancers like Hodgkin’s lymphoma by inhibiting microtubule formation and cell division.

Structure of Vinblastine Sulphate

• Vinblastine is a vinca alkaloid comprising two monomers: catharanthine and vindoline, linked together.
• Chemical Formula: C₄₈H₅₈N₁₄O₁₂

Mode of Action

• Microtubule Inhibition: Binds to tubulin, preventing microtubule assembly and disassembly.
• Mitotic Arrest: Halts cell division at metaphase by disrupting spindle formation.
• Apoptosis Induction: Leads to programmed cell death in rapidly dividing cells.

Uses

• Hodgkin’s Lymphoma: Often part of ABVD regimen.
• Non-Hodgkin’s Lymphoma: In various treatment protocols.
• Breast Cancer: Especially metastatic cases.
• Testicular Cancer: In combination with other chemotherapeutic agents.
• Bladder Cancer: As part of multi-agent chemotherapy regimens.

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