Vincristine Sulphate is an anti-neoplastic agent used in leukemia and lymphomas by inhibiting microtubule assembly and cell division.
Structure of Vincristine Sulphate
- Vincristine is another vinca alkaloid similar to Vinblastine, comprising the same monomers: catharanthine and vindoline, but with slight structural variations.
- Chemical Formula: C₂₇H₂₈N₄O₁₂
Mode of Action
- Microtubule Inhibition: Binds to tubulin, preventing microtubule polymerization.
- Mitotic Arrest: Blocks cell division at metaphase by disrupting spindle formation.
- Apoptosis Induction: Triggers programmed cell death in rapidly dividing cells.
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Uses
- Acute Lymphoblastic Leukemia (ALL): Particularly in pediatric cases.
- Non-Hodgkin’s Lymphoma: In various treatment protocols.
- Hodgkin’s Lymphoma: As part of combination chemotherapy.
- Breast Cancer: Especially metastatic forms.
- Kaposi’s Sarcoma: In certain treatment regimens.
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