Vincristine Sulphate

Vincristine Sulphate is an anti-neoplastic agent used in leukemia and lymphomas by inhibiting microtubule assembly and cell division.

Structure of Vincristine Sulphate

• Vincristine is another vinca alkaloid similar to Vinblastine, comprising the same monomers: catharanthine and vindoline, but with slight structural variations.
• Chemical Formula: C₂₇H₂₈N₄O₁₂

Mode of Action

• Microtubule Inhibition: Binds to tubulin, preventing microtubule polymerization.
• Mitotic Arrest: Blocks cell division at metaphase by disrupting spindle formation.
• Apoptosis Induction: Triggers programmed cell death in rapidly dividing cells.

Uses

• Acute Lymphoblastic Leukemia (ALL): Particularly in pediatric cases.
• Non-Hodgkin’s Lymphoma: In various treatment protocols.
• Hodgkin’s Lymphoma: As part of combination chemotherapy.
• Breast Cancer: Especially metastatic forms.
• Kaposi’s Sarcoma: In certain treatment regimens.

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