Ideal Solubility Parameters
- S-3-PHYSICAL-PHARMACEUTICS
- Feb 28
- 1 min read
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Ideal solubility parameters provide a quantitative measure of the solubility of substances.
They are based on the concept that similar intermolecular forces between solute and solvent lead to better solubility.
The most common parameter is the Hildebrand solubility parameter (δ), which is defined as:
Where:
ΔHv = Enthalpy of vaporization
R = Universal gas constant
T = Temperature in Kelvin
Vm = Molar volume
Ideal Solubility Concept
For a solute to dissolve ideally in a solvent, their solubility parameters should be similar.
This is often summarized by the "like dissolves like" principle:
Polar solutes dissolve better in polar solvents.
Non-polar solutes dissolve better in non-polar solvents.
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