Imidazole is a five-membered aromatic heterocycle with two non-adjacent nitrogen atoms, widely used in drugs.
Chemical Formula of Imidazole:
- C₃H₄N₂
Physical Properties of Imidazole:
| Property | Value |
| Appearance | White crystalline solid |
| Melting Point | ~90–91 °C |
| Boiling Point | ~257 °C |
| Solubility | Very soluble in water and polar solvents |
| Basicity | More basic than pyrazole |
Medicinal Uses:
- Present in biological molecules and many drugs.
- Histidine (amino acid) contains imidazole.
- Examples:
- Metronidazole: Antimicrobial
- Cimetidine: H₂-receptor blocker
- Ketoconazole: Antifungal
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