Polymerization

Definition of Polymerization:

• Polymerization is the linking of monomer units to form larger molecular structures, which can cause undesirable changes in drug properties.

Examples:

1. Example Reaction (Addition Polymerization of Formaldehyde):
   • n(HCHO) → (–CH₂–O–)ₙ
2. Example Reaction (Condensation Polymerization of Amino Acids):
   • RCOOH + R’NH₂ → RCONHR’ + H₂O

Prevention Strategies of Polymerization:

• Use stabilizers and appropriate solvents.
• Control temperature and pH to avoid polymerization.

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