Definition of Polymerization:
- Polymerization is the linking of monomer units to form larger molecular structures, which can cause undesirable changes in drug properties.
Examples:
- Example Reaction (Addition Polymerization of Formaldehyde):
- n(HCHO) → (–CH₂–O–)ₙ
- Example Reaction (Condensation Polymerization of Amino Acids):
- RCOOH + R’NH₂ → RCONHR’ + H₂O
Prevention Strategies of Polymerization:
- Use stabilizers and appropriate solvents.
- Control temperature and pH to avoid polymerization.
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