Production of Soft Gelatin Capsules

• Production of Soft Gelatin Capsules ensures precise dosing, improved bioavailability, and enhanced stability of sensitive formulations.
• It ensures precise dosing, improved bioavailability, and enhanced stability of sensitive formulations.
• The production of soft gelatin capsules involves the following steps:

1. Formulation of Fill Material:

   • Drugs are dissolved or suspended in a suitable vehicle (e.g., oils, polyethylene glycol, or other non-aqueous solvents).
   • The formulation is homogenized to ensure uniformity.

2. Preparation of Gelatin Mass:

   • Gelatin, plasticizers, and other components are mixed with water and heated under vacuum to remove air bubbles.
   • The gelatin mass is held at a controlled temperature (~50°C) to maintain its fluidity.

3. Encapsulation Process:

   • The encapsulation is typically performed using a rotary die process:
   • Two ribbons of gelatin are formed and fed into the rotary die machine.
   • The fill material is injected between the ribbons.
   • The ribbons are sealed and cut into individual capsules.

4. Drying:

   • Capsules are tumbled in rotating drums to remove excess moisture.
   • Further drying occurs in controlled drying tunnels with regulated temperature (20-25°C) and humidity (20-30

5. Inspection and Sorting:

   • Capsules are visually inspected for defects like leaks, cracks, or improper sealing.
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