Propylhexedrine

• Propylhexedrine is a synthetic stimulant drug primarily used as a nasal decongestant.
• It is structurally related to amphetamines and works by constricting blood vessels in the nasal passages, which reduces swelling and congestion.

Chemical Structure & Formula

• Chemical Formula: C₁₀H₁₅N
• Structure:
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Mechanism of Action (Detailed)

• Increases norepinephrine release from presynaptic nerve terminals.
• Mild dopamine release → Weak CNS stimulant effects.
• No direct adrenergic receptor activity.

Physiological Effects

1. Cardiovascular:

   • Increases BP (α1 activation via norepinephrine).
   • Increases HR (β1 activation via norepinephrine).

2. CNS:

   • Mild stimulant effects (weaker than amphetamine).

3. Respiratory:

   • Nasal decongestant (vasoconstriction in nasal mucosa).

Side Effects of Propylhexedrine

• Hypertension, Palpitations
• Anxiety, Insomnia
• Dizziness, Headache

Clinical Uses of Propylhexedrine

• Nasal decongestant (inhaler formulation).
• Mild CNS stimulant (off-label use).

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