Type 2 Diabetes

Type 2 Diabetes Introduction

  • Type 2 diabetes, previously known as adult-onset diabetes or non-insulin-dependent diabetes.
  • The most common form of diabetes.
  • Characterized by insulin resistance and relative insulin deficiency.

Causes of Type 2 diabetes

  1. Genetic Factors

    • Family history increases risk.
  2. Lifestyle Factors

    • Obesity, physical inactivity, poor diet, and aging.
  3. Metabolic Syndrome

    • A cluster of conditions: high blood pressure, high blood sugar, abnormal cholesterol levels, and excess body fat around the waist.
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Symptoms

  • Increased thirst and urination
  • Increased hunger
  • Fatigue
  • Blurred vision
  • Slow-healing sores or frequent infections
  • Acanthosis Nigricans
    • Areas of darkened skin, often in the armpits and neck.

Pathophysiology of Type 2 Diabetes:

Pathophysiology of Type 2 Diabetes
Pathophysiology of Type 2 Diabetes
  1. Insulin Resistance: Cells in the body become less responsive to insulin.
  2. Beta Cell Dysfunction: The pancreas produces less insulin over time.
  3. Hyperglycemia: Persistently high blood glucose levels due to the combination of insulin resistance and reduced insulin production.
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Diagnosis

  1. Fasting Blood Glucose Test: Elevated glucose levels after fasting.
  2. A1C Test: Measures average blood glucose levels over the past 2-3 months.
  3. Oral Glucose Tolerance Test (OGTT): Elevated blood glucose levels after consuming a glucose drink.

Treatment

  1. Lifestyle Changes: Healthy eating, regular physical activity, and weight loss.
  2. Medications: Oral medications (e.g., metformin) and sometimes insulin or other injectable medications.
  3. Blood Glucose Monitoring: Regular monitoring to manage blood glucose levels.
  4. Education and Support: Diabetes education programs for self-management skills.
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